Journal
JOURNAL OF CARDIAC FAILURE
Volume 17, Issue 12, Pages 1012-1017Publisher
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.cardfail.2011.08.008
Keywords
Pulmonary hypertension; endothelial function; oxidative stress; endothelial superoxide dismutase
Categories
Funding
- FONDECYT [1050768]
- FONDAP [15010006]
- CONICYT, Chile
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Background: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with acute pulmonary vascular bed response to an inhaled prostanoid in PAM patients. Methods: Fourteen idiopathic PAH patients and 14 controls were included. Oxidative stress was assessed through plasma malondialdehyde (MDA) levels and xanthine oxidase (XO) and endothelial-bound superoxide dismutase (eSOD) activity. Brachial artery endothelial-dependent flow-mediated vasodilation (FMD) was used to evaluate endothelial function. Hemodynamic response to inhaled iloprost was assessed with transthoracic echocardiography. Results: PAH patients showed impaired FMD (2.8 +/- 0.6 vs. 10.7 +/- 0.6%, P < .01), increased MDA levels and XO activity (0.6 +/- 0.2 vs. 0.3 +/- 0.2 mu M, P < .01 and 0.04 +/- 0.01 vs. 0.03 +/- 0.01 U/mL, P = .02, respectively) and decreased eSOD activity (235 +/- 23 vs. 461 +/- 33 AUC, P < .01). Iloprost improved right cardiac output (3.7 +/- 0.6 to 4.1 +/- 1.2 L/min, P = .02) and decreased pulmonary vascular resistance (4.1 +/- 1.1 to 2.9 +/- 0.9 Wood U, P = .01). Changes in right cardiac output after prostanoid inhalation correlated significantly with baseline eSOD activity and FMD (Rho: 0.61, P < .01 and Rho: 0.63, P = .01, respectively). Conclusion: PAH patients show increased systemic oxidative stress and endothelial dysfunction markers. Response to inhaled prostanoid is inversely related to both parameters. (J Cardiac Fail 2011;17:1012-1017)
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