Journal
JOURNAL OF CARDIAC FAILURE
Volume 14, Issue 7, Pages 603-614Publisher
CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
DOI: 10.1016/j.cardfail.2008.02.011
Keywords
medication compliance; model testing; MEMS
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Funding
- Philips Medical-American Association
- University of Kentucky General Clinical Research Center [M01RR02602]
- Gill Endowment
- National Institute of Nursing Research [R01NR008567]
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR002602] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NURSING RESEARCH [R01NR008567] Funding Source: NIH RePORTER
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Background: Medication adherence in heart failure (HF) is a crucial but poorly understood phenomenon. The Purpose of this study was to explore factors contributing to medication adherence in patients with HF by using the World Health Organization's multidimensional adherence model. Methods and Results: Patients (N = 134) with HF (70% were male, aged 61 +/- 12 years, 61% with New York Heart Association III/IV) were Studied to determine the predictors of medication adherence derived from the Multidimensional adherence model. Medication adherence was measured objectively using the medication event monitoring system for 3 months. Three indicators of adherence were assessed by the medication event monitoring system: 1) does-count, the percentage of prescribed doses taken; 2) dose-days, the percentage of days the correct number of doses were taken and 3) dose-time, the percentage of doses that were taken on schedule. Barriers to medication adherence, ethnicity, and perceived social Support predicted dose-count (P < .001). New York Heart Association functional class, barriers to medication adherence, financial status, and perceived social Support predicted dose-day (P < .001). Barriers to medication adherence and financial status predicted dose-time (P = .005). Conclusion: A number of modifiable factors predicted medication adherence in patients with HF, providing specific targets for intervention.
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