Journal
NEUROBIOLOGY OF DISEASE
Volume 80, Issue -, Pages 63-69Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2015.05.009
Keywords
ALS; Iron; Motor neuron death; TNF-alpha; TNF-alpha converting enzyme (TACE)
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Funding
- National Research Foundation - Ministry of Science, ICT & Future Planning of Korea [2006-0093855]
- Korea University
- National Research Foundation [2014R1A1A1002076, 2014R1A1A3052540]
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Oxidative stress contributes to degeneration of motor neurons in patients with amyotrophic lateral sclerosis (ALS) as well as transgenic mice overexpressing ALS-associated human superoxide dismutase 1 (SOD1) mutants. However, the molecular mechanism by which the ALS-linked SOD1 mutants including SOD1(G93A) induce oxidative stress remains unclear. Here, we show that iron was accumulated in ventral motor neurons from SOD1(G93A)-transgenic mice even at 4 weeks of age, subsequently inducing oxidative stress. Iron chelation with deferoxamine mesylate delayed disease onset and extended lifespan of SOD1(G93A) mice. Furthermore, SOD1(G93A)-induced iron accumulation mediated the increase in the enzymatic activity of TNF-alpha converting enzyme (TACE), leading to secretion of TNF-alpha at least in part through iron-dependent oxidative stress. Our findings suggest iron as a key determinant of early motor neuron degeneration as well as proinflammatory responses at symptomatic stage in SOD1(G93A) mice. (C) 2015 Elsevier Inc. All rights reserved.
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