Journal
JOURNAL OF CARBOHYDRATE CHEMISTRY
Volume 31, Issue 4-6, Pages 504-518Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07328303.2012.661112
Keywords
Cancer stem cells; Pancreatic cancer; Paucimannose glycan; Pancreatitis; Biomarker
Funding
- Michigan State University [04-IRGP-109]
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The trimannosyl structure, also called paucimannose, is characteristic for all eukaryotic N-glycans. The unmodified structure is expressed abundantly in plants and invertebrates, whereas in normal mammalian tissue it has been detected in only very small amounts. We have developed a monoclonal antibody called Mannitou that specifically recognizes paucimannose and clearly stains all human cancer tissues analyzed, human adult pancreatic stem cells, and inflamed mouse pancreata. Normal tissues/cells exhibited only weak or no staining. The up-regulation of paucimannose under tumorigenic and inflammatory conditions makes the Mannitou antibody a promising tool for diagnosis and potential therapeutic applications.
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