Journal
JOURNAL OF CARBOHYDRATE CHEMISTRY
Volume 31, Issue 4-6, Pages 384-419Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07328303.2012.658274
Keywords
Sulfated carbohydrates; Solid-phase synthesis; Protecting groups; Glycosaminoglycans; Heparan sulfate
Funding
- National Institutes of Health [GM-06982]
Ask authors/readers for more resources
Mono- and disaccharides of sulfonated glucosamines (GlcN sulfoforms) conjugated to 2-aminoethyl linkers were generated by solid-phase synthesis. Orthogonally protected intermediates were tethered onto tritylated polystyrene resin beads, subjected to a modular sequence of deprotection and sulfonation steps, then cleaved from solid support without degradation of N- or O-sulfate esters using solvolytic conditions, and finally purified by reverse-phase HPLC to afford the title compounds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available