Journal
JOURNAL OF CARBOHYDRATE CHEMISTRY
Volume 29, Issue 3, Pages 118-132Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07328303.2010.483042
Keywords
Cancer; Chemical Engineering; N-Glycan; Lymphocytes; Noninvasive Imaging; 6-Azaelectrocyclization
Funding
- Japan Science and Technology Agency (JST) [19681024, 19651095]
- New Energy and Industrial Technology Development Organization [07A01014a]
- Yamada Science Foundation
- Molecular Imaging Research Program
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
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[image omitted]Graphical Abstract Combined azaelectrocyclization and Staudinger ligation allowed proteins and living cells to be modified by small molecules (i.e., biotin or N-glycans). Chemically engineered lymphocytes modified by complex-type N-glycan targeted DLD-1 tissues implanted in nude mice at the whole-body level.
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