Journal
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
Volume 8, Issue 4, Pages 549-554Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/0973-1482.106534
Keywords
Cannabinoid; melanoma; receptor
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Aims: To investigate the expression of CB2 in normal skin, pigmented nevus, and malignant melanoma; analyze its relation with genesis; and development of malignant melanoma. Materials and Methods: In our study, we detected the expression of CB2 in 20 cases of melanoma, nevus tissue, and normal skin tissues, respectively, by using immunohistochemistry, in situ hybridization, and RT-PCR. Moreover, we investigated the localization and expression of CB2 in human melanoma cell line A375 and human immortalized keratinocyte cell line HaCaT by using immunofluorescence and western blotting. Results: Our data revealed that CB2 is unregulated in melanoma. Conclusions: CB2 plays a role in the development of melanoma.
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