Journal
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
Volume 6, Issue 4, Pages 487-491Publisher
MEDKNOW PUBLICATIONS
DOI: 10.4103/0973-1482.77106
Keywords
Malondialdehyde; oral cancer; oral precancer
Categories
Ask authors/readers for more resources
Background: Tobacco and alcohol induces generation of free radicals and reactive oxygen species, which are responsible for high rate of lipid peroxidation. Malondialdehyde is the most widely used marker of lipid peroxidation. The aim of the study was to estimate serum malondialdehyde level in oral precancer, oral cancer, and normal individuals. Materials and Methods: In this study serum malondialdehyde was measured according to the method of Ohkawa et al in 30 normal individuals and 30 patients each with histopathologically diagnosed oral precancer, and oral cancer. Results: The mean serum malondialdehyde level in the control group was found to be 5.107 +/- 2.32.mol/ml, whereas it was 9.33 +/- 4.89.mol/ml and 14.34 +/- 1.43.mol/ml in oral precancer and oral cancer, respectively. There was statistically significant increase in serum malondialdehyde levels in the oral precancer and oral cancer patients compared with the control group. Conclusion: Increased serum malondialdehyde in oral cancer and oral precancer would serve as a valuable marker for both preventive and clinical intervention, and may deserve further investigation for the early diagnosis, treatment, and prognosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available