Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 140, Issue 11, Pages 1891-1899Publisher
SPRINGER
DOI: 10.1007/s00432-014-1759-3
Keywords
LASP-1; Metastasis; Prognosis; Gastric cancer
Categories
Funding
- Shandong Province Medicine and Health Science Technology Program [2013WS0279]
- Shandong Province Natural Science Foundation [ZR2010HM006, ZR2010HM087]
- Shandong Province Higher Educational Science and Technology Program [J11LF14, J12LK51]
- Science and Technology Program of Weifang medical university [K1301001]
- science and technology innovation fund projects of Weifang medical university student [KX2013001]
- Shandong Province Taishan scholar project
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The LIM and SH3 protein 1 (LASP-1) is a focal adhesion protein, and its expression has been reported to be increased in many malignant tumors. However, the role of LASP-1 in gastric cancer is still unknown. The aim of this study was to determine the relationship of LASP-1 expression with the progression and prognosis of gastric cancer. Expression of LASP-1 was evaluated in gastric cancer tissues and cell lines by immunohistochemistry and Western blot analysis. The relationship between LASP-1 expression and clinicopathological characteristics was analyzed. Using RNA interference, the effects of LASP-1 on cell proliferation, migration and invasion were investigated in gastric cancer cell lines both in vitro and in vivo. The LASP-1 was overexpressed in gastric cancer tissues and cell lines. LASP-1 expression was significantly associated with tumor size, invasive depth, TNM stage, lymph node metastasis and p53 expression (all P < 0.05). Multivariate survival analysis showed that LASP-1 expression was recognized as an independent prognostic factor of patient's survival. Knockdown of LASP-1 inhibited cell proliferation, migration and invasion in vitro as well as tumorigenesis and metastasis in vivo. Our study showed that LASP-1, overexpressed in gastric cancer and associated with poor prognosis, plays an important role in the growth and metastasis of gastric cancer.
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