Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 141, Issue 8, Pages 1333-1341Publisher
SPRINGER
DOI: 10.1007/s00432-014-1831-z
Keywords
Regucalcin; Cell signaling; Carcinogenesis; Gene therapy; Cancer
Categories
Funding
- Ministry of Education, Science, Sports and Culture, Japan [63571053, 02671006, 04671362, 06672193, 08672522, 10672048, 13672292, 17590063]
- Bounty of Encouragement Foundation in Pharmaceutical Research
- Bounty of the Yamanouchi Foundation for Research on Metabolic Disorders, Japan
- Foundation for Biomedical Research on Regucalcin
- Grants-in-Aid for Scientific Research [17590063, 10672048, 04671362, 08672522, 63571053, 02671006] Funding Source: KAKEN
Ask authors/readers for more resources
Regucalcin, which its gene is located on the X chromosome, plays a multifunctional role as a suppressor protein in cell signal transduction in various types of cells and tissues. The suppression of regucalcin gene expression has been shown to involve in carcinogenesis. Regucalcin gene expression was uniquely downregulated in carcinogenesis of rat liver in vivo, although the expression of other many genes was upregulated, indicating that endogenous regucalcin plays a suppressive role in the development of hepatocarcinogenesis. Overexpression of endogenous regucalcin was found to suppress proliferation of rat cloned hepatoma cells in vitro. Moreover, the regucalcin gene and its protein levels were demonstrated specifically to downregulate in human hepatocellular carcinoma by analysis with multiple gene expression profiles and proteomics. Regucalcin gene expression was also found to suppress in human tumor tissues including kidney, lung, brain, breast and prostate, suggesting that repressed regucalcin gene expression leads to the development of carcinogenesis in various tissues. Regucalcin may play a role as a suppressor protein in carcinogenesis. Overexpression of endogenous regucalcin is suggested to reveal preventive and therapeutic effects on carcinogenesis. Delivery of the regucalcin gene may be a novel useful tool in the gene therapy of carcinogenesis. This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available