Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 138, Issue 4, Pages 671-674Publisher
SPRINGER
DOI: 10.1007/s00432-012-1147-9
Keywords
Cervical cancer; microRNAs; Invasion; Metastasis
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Funding
- Wuxi medical management center [YGM1016]
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microRNA-218 was proved to be a tumor-suppressor microRNA in several cancers, but its status in cervical cancer patients has not been established. In this study, we investigated the expression of microRNA-218 in the sera from cervical cancer patients and its relationships with clinico-pathological characteristics. The expression of microRNA-218 was detected in the sera of 90 cervical cancer patients and 50 normal age-matched women by quantitative real-time PCR. The clinical data were collected and analyzed by statistical software. In the cancer group, microRNA-218 was reduced significantly in the sera (P < 0.001). Moreover, decreased microRNA-218 was associated with later stages, cervical adenocarcinoma, and lymphatic node metastasis. microRNA-218 was deregulated in most cervical cancer patients and associated with tumor invasion.
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