Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 136, Issue 4, Pages 603-610Publisher
SPRINGER
DOI: 10.1007/s00432-009-0698-x
Keywords
Cucurbitacin E; p53; PANC-1; Pancreatic cancer; STAT3
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Funding
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [20060331]
- Natural Science Foundation of Liaoning Province, China [20082092]
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Pancreatic cancer has been a serious disease worldwide for its high mortality. Cucurbitacin E is a member of triterpenoid family isolated from plants showing antiproliferative activity on various cancer cells. In this study, we have explored whether cucurbitacin E also has an anti-tumor effect on pancreatic cancer cells. Human pancreatic cancer cells PANC-1 were used to explore the effect and possible mechanisms of cucurbitacin E on cell cycle progression, apoptosis and proliferation. Cucurbitacin E has inhibited the growth of PANC-1 cells in a dose- and time-dependent manner, and has caused accumulation of cells at the G(2)/M phase as well as apoptosis. Western blotting also showed that cucurbitacin E treatment can inhibit STAT3 phosphorylation while upregulate p53 expression. Our results suggested that cucurbitacin E may be an effective regimen for the chemotherapy of pancreatic cancer.
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