Journal
NEUROBIOLOGY OF AGING
Volume 36, Issue 2, Pages 1097-1104Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.10.029
Keywords
Substantia nigra; Parkinson's disease; Diffusion MRI; Free-water mapping
Categories
Funding
- National Institutes of Health [R01 NS052318, R01 NS075012]
- Bachmann-Strauss Dystonia and Parkinson Foundation
- Michael J. Fox Foundation for Parkinson's Research
- Abbott
- Avid Radiopharmaceuticals
- Biogen Idec
- Bristol-Myers Squibb
- Covance
- Elan
- GE Healthcare
- Genentech
- GlaxoSmithKline
- Eli Lilly and Company
- Merck
- Meso Scale Discovery
- Pfizer Inc.
- Roche Inc.
- UCB Inc.
- Bachmann-Strauss Center of Excellence
- NPF Center of Excellence
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Measures from diffusion magnetic resonance imaging reflect changes in the substantia nigra of Parkinson's disease. It is the case, however, that partial volume effects from free water can bias diffusion measurements. The bi-tensor diffusion model was introduced to quantify the contribution of free water and eliminates its bias on estimations of tissue microstructure. Here, we test the hypothesis that free water is elevated in the substantia nigra for Parkinson's disease compared with control subjects. This hypothesis was tested between large cohorts of Parkinson's disease and control participants in a single-site study and validated against a multisite study using multiple scanners. The fractional volume of free water was increased in the posterior region of the substantia nigra in Parkinson's disease compared with control subjects in both the single-site and multi-site studies. We did not observe changes in either cohort for free-water-corrected fractional anisotropy or free-water-corrected mean diffusivity. Our findings provide new evidence that the free-water index reflects alteration of the substantia nigra in Parkinson's disease, and this was evidenced across both single-site and multi-site cohorts. (C) 2015 Elsevier Inc. All rights reserved.
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