Journal
NEUROBIOLOGY OF AGING
Volume 36, Issue -, Pages S203-S210Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.01.154
Keywords
Alzheimer's disease; MRI; Cortical; Gray matter; Atrophy; Thickness; Volume; Surface area; Brain structure; Homocysteine; Folate; Vitamin B
Categories
Funding
- National Defense Science and Engineering Graduate (NDSEG) Fellowship [32 CFR 168a]
- U.S. Department of Defense
- Air Force Office of Scientific Research
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health) [U01 AG024904]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- Abbott
- AstraZeneca AB
- Bayer Schering Pharma AG
- Bristol-Myers Squibb
- Eisai Global Clinical Development
- Elan Corporation
- Genentech
- GE Healthcare
- GlaxoSmithKline
- Innogenetics
- Johnson and Johnson
- Eli Lilly and Company
- Medpace, Inc
- Merck and Co, Inc
- Novartis AG
- Pfizer
- F. Hoffman-La Roche
- Schering-Plough
- Synarc, Inc
- Wyeth
- Alzheimer's Association and Alzheimer Drug Discovery Foundation
- Northern California Institute for Research and Education
- National Institutes of Health [P30 AG010129, K01 AG030514]
- Dana Foundation
- U.S. Food and Drug Administration
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A significant portion of our risk for dementia in old age is associated with lifestyle factors (diet, exercise, and cardiovascular health) that are modifiable, at least in principle. One such risk factor, high-homocysteine levels in the blood, is known to increase risk for Alzheimer's disease and vascular disorders. Here, we set out to understand how homocysteine levels relate to 3D surface-based maps of cortical gray matter distribution (thickness, volume, and surface area) computed from brain magnetic resonance imaging in 803 elderly subjects from the Alzheimer's Disease Neuroimaging Initiative data set. Individuals with higher plasma levels of homocysteine had lower gray matter thickness in bilateral frontal, parietal, occipital, and right temporal regions and lower gray matter volumes in left frontal, parietal, temporal, and occipital regions, after controlling for diagnosis, age, and sex and after correcting for multiple comparisons. No significant within-group associations were found in cognitively healthy people, patients with mild cognitive impairment, or patients with Alzheimer's disease. These regional differences in gray matter structure may be useful biomarkers to assess the effectiveness of interventions, such as vitamin B supplements, that aim to prevent homocysteine-related brain atrophy by normalizing homocysteine levels. (C) 2015 Elsevier Inc. All rights reserved.
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