Journal
NEUROBIOLOGY OF AGING
Volume 36, Issue 6, Pages 2018-2023Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2015.03.001
Keywords
Cortical thickness; YKL-40; Neuroinflammation; Preclinical Alzheimer's disease; CSF biomarkers; Structural MRI
Categories
Funding
- Instituto de Salud Carlos III (BIOMARKAPD-Joint Programming on Neurodegenerative Diseases) [PI11/03035]
- Instituto de Salud Carlos III (DEMTEST-Joint Programming on Neurodegenerative Diseases) [PI12/02288, PI11/03028]
- Centro de Investigacion Biomedica en Red en enfermedades Neurodegenerativas (CIBERNED)
Ask authors/readers for more resources
Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-beta 1-42 [A beta 42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as A beta 42+ (<550 pg/mL) or A beta 42- (>550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in A beta 42+ subjects but not in A beta 42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process. (C) 2015 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available