Journal
NEUROBIOLOGY OF AGING
Volume 36, Issue 2, Pages 903-908Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2014.08.031
Keywords
Alzheimer's disease; Cortical thinning; Early detection; Longitudinal; Mild cognitive impairment
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Funding
- Intramural Research Program of the National Institutes of Health, National Institute on Aging
- Research and Development Contract [N01-AG-3-2124]
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Cross-sectional studies have shown regional differences in cortical thickness between healthy older adults and patients with Alzheimer's disease (AD) or mild cognitive impairment (MCI). We now demonstrate that participants who subsequently develop cognitive impairment leading to a diagnosis of MCI or AD (n = 25) experience greater cortical thinning in specific neuroanatomic regions compared with control participants who remained cognitively normal (n = 96). Based on 8 years of annual magnetic resonance imaging scans beginning an average of 11 years before onset of cognitive impairment, participants who developed cognitive impairment subsequent to the scanning period had greater longitudinal cortical thinning in the temporal poles and left medial temporal lobe compared with controls. No significant regional cortical thickness differences were found at baseline between the 2 study groups indicating that we are capturing a critical time when brain changes occur before behavioral manifestations of impairment are detectable. Our findings suggest that early events of the pathway that leads to cognitive impairment may involve the temporal lobe and that this increased atrophy could be considered an early biomarker of neurodegeneration predictive of cognitive impairment years later. Published by Elsevier Inc.
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