Journal
NEUROBIOLOGY OF AGING
Volume 36, Issue 9, Pages 2458-2467Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2015.05.015
Keywords
Connectome; Brain networks; Cognitive fluctuations; Attention impairment; Resting-state
Categories
Funding
- Intermediate Clinical Fellowship [WT088441MA]
- National Institute for Health Research (NIHR)
- Human Green Brain Project through EPSRC [EP/K026992/1]
- Newcastle Biomedical Research Unit (BRU) based at Newcastle upon Tyne Hospitals NHS Trust
- Newcastle University
- EPSRC [EP/K026992/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K026992/1] Funding Source: researchfish
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The clinical phenotype of dementia with Lewy bodies (DLB) is different from Alzheimer's disease (AD), suggesting a divergence between these diseases in terms of brain network organization. To fully understand this, we studied functional networks from resting-state functional magnetic resonance imaging in cognitively matched DLB and AD patients. The DLB group demonstrated a generalized lower synchronization compared with the AD and healthy controls, and this was more severe for edges connecting distant brain regions. Global network measures were significantly different between DLB and AD. For instance, AD showed lower small-worldness than healthy controls, while DLB showed higher small-worldness (AD < controls < DLB), and this was also the case for global efficiency (DLB > controls > AD) and clustering coefficient (DLB < controls < AD). Differences were also found for nodal measures at brain regions associated with each disease. Finally, we found significant associations between network performance measures and global cognitive impairment and severity of cognitive fluctuations in DLB. These results show network divergences between DLB and AD which appear to reflect their neuropathological differences. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.
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