Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 29, Issue 9, Pages 1917-1925Publisher
WILEY
DOI: 10.1002/jbmr.2286
Keywords
BONE MASS; GROWTH; INTRAUTERINE; LIFECOURSE; FRACTURE; EPIGENETIC; VITAMIN D
Categories
Funding
- Medical Research Council (UK)
- Arthritis Research UK
- National Osteoporosis Society (UK)
- International Osteoporosis Foundation
- NIHR Southampton Biomedical Research Centre
- NIHR Oxford Musculoskeletal Biomedical Research Unit
- Medical Research Council [MC_UU_12011/1, MC_UP_A620_1014, U1475000001] Funding Source: researchfish
- National Institute for Health Research [10/33/04, NF-SI-0508-10082, NF-SI-0513-10085] Funding Source: researchfish
- Versus Arthritis [17702] Funding Source: researchfish
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It is becoming increasingly apparent that the risk of developing osteoporosis is accrued throughout the entire lifecourse, even from as early as conception. Thus early growth is associated with bone mass at peak and in older age, and risk of hip fracture. Novel findings from mother-offspring cohorts have yielded greater understanding of relationships between patterns of intrauterine and postnatal growth in the context of later bone development. Study of biological samples from these populations has helped characterize potential mechanistic underpinnings, such as epigenetic processes. Global policy has recognized the importance of early growth and nutrition to the risk of developing adult chronic noncommunicable diseases such as osteoporosis; testing of pregnancy interventions aimed at optimizing offspring bone health is now underway. It is hoped that through such programs, novel public health strategies may be established with the ultimate goal of reducing the burden of osteoporotic fracture in older age. (C) 2014 American Society for Bone and Mineral Research.
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