Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 29, Issue 8, Pages 1709-1714Publisher
WILEY
DOI: 10.1002/jbmr.2252
Keywords
VITAMIN D; STANDARDIZATION; VITAMIN D STANDARDIZATION PROGRAM; VDSP; 25-HYDROXYVITAMIN D
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Funding
- NIH National Center on Minority Health and Health Disparities (NCMHD) Comprehensive Centers of Excellence [1P60/R01 MD 003428-01]
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For a number of years it has been widely assumed that measurement of serum 25-hydroxyvitamin D [25(OH)D] concentration is the best approach to assessing an individual's vitamin D status.((1,2)) However, it has also been recognized that there is substantial within-assay variation in 25(OH)D measurement and even greater between-assay variability.((3-5)) Such assay variation clearly confounds attempts to define what constitutes the diagnosis of hypovitaminosis D. Importantly, assay variability makes pooling of 25(OH)D results from different studies in systematic reviews for the specific purpose of determining dose-response and/or clinical cut points at best problematic. Therefore, to develop and implement evidence-based clinical guidelines, it is essential that 25(OH)D measurement be standardized in both clinical and research laboratories. In this Perspective we outline a way forward toward achieving this goal-the Vitamin D Standardization Program (VDSP). (C) 2014 American Society for Bone and Mineral Research
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