Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 28, Issue 5, Pages 992-996Publisher
WILEY
DOI: 10.1002/jbmr.1838
Keywords
HVDRR; CINACALCET; INTRAVENOUS CALCIUM; VDR; RICKETS
Categories
Funding
- Sam and Helen Kaplan Research Fund in Pediatric Nephrology
- Eric McClure Research Fund in Pediatric Bone and Mineral Disorders
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Secondary hyperparathyroidism from inadequate calcium absorption in the gut, is the underlying pathophysiology for rachitic changes in hereditary vitamin Dresistant rickets (HVDRR). We describe a novel use of Cinacalcet to treat a child with HVDRR in whom conventional modes of therapy had to be discontinued. Cinacalcet therapy with high-dose oral calcium effectively normalized the metabolic abnormalities and bone condition. The relative ease of administration of the calcimimetic as a once- or twice-daily oral preparation, compared with traditional intravenous calcium administration, should encourage its move to the frontline of treatment of the disorder. (c) 2013 American Society for Bone and Mineral Research.
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