Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 27, Issue 3, Pages 499-505Publisher
WILEY
DOI: 10.1002/jbmr.1547
Keywords
OSTEOCYTE; OSTEOBLAST; OSTEOCLAST; RANKL; BONE REMODELING
Categories
Funding
- National Institutes of Health [AR049794, AG13918]
- Department of Veterans Affairs
- UAMS Translational Research Institute [1UL1RR029884]
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The idea that osteoblasts, or their progenitors, support osteoclast formation by expressing the cytokine receptor activator of NFkB ligand (RANKL) is a widely held tenet of skeletal biology. Two recent studies provide evidence that osteocytes, and not osteoblasts or their progenitors, are the major source of RANKL driving osteoclast formation in cancellous bone. The goal of this review is to highlight the results of these new studies and discuss their implications for our understanding of bone remodeling. (c) 2012 American Society for Bone and Mineral Research
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