Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 27, Issue 1, Pages 170-176Publisher
WILEY
DOI: 10.1002/jbmr.524
Keywords
CHOLECALCIFEROL SUPPLEMENTATION; FALLS; MUSCLE STRENGTH; MOBILITY; OLDER WOMEN
Categories
Funding
- Department of Health
- Western Australia State Health Research Advisory Council
- Sir Charles Gairdner Hospital Research Advisory Committee
- Royal Perth Hospital Medical Research Foundation
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Daily vitamin D in addition to calcium supplementation reduces falls and fractures in older women. However, poor adherence to therapy is a common clinical problem. To examine the effects of supervised oral 3-monthly vitamin D therapy on falls, muscle strength, and mobility, we conducted a 9-month randomized, double-blind, placebo-controlled trial in 686 community-dwelling ambulant women aged over 70 years. Participants received either oral cholecalciferol 150,000 IU every 3 months (n=353) or an identical placebo (n=333). All participants were advised to increase dietary calcium intake. Falls data were collected 3-monthly. At baseline, 3, 6, and 9 months, muscle strength was measured by a handheld dynamometer and mobility by the Timed Up and Go (TUG) test. Serum 25 hydroxyvitamin D (25OHD) was measured in a subgroup of 40 subjects. Mean age at baseline was 76.7 +/- 4.1 years. The average serum 25OHD value at baseline was 65.8 +/- 22.7 nmol/L. By 3, 6, and 9 months after supplementation, 25OHD levels of the vitamin D group were approximately 15?nmol/L higher than the placebo group. Calcium intake did not change significantly between baseline (864 +/- 412 mg/day) and 9 months (855 +/- 357 mg/day). Faller rates in the two groups did not differ: vitamin D group, 102 of 353 (29%); placebo group, 89 of 333 (27%). At 9 months, compared to placebo or baseline, muscle strength, and TUG were not altered by vitamin D. In conclusion, oral cholecalciferol 150,000 IU therapy administered 3-monthly had neither beneficial nor adverse effects on falls or physical function. These data together with previous findings confirm that intermittent large doses of vitamin D are ineffective or have a deleterious effect on falls. Thus despite adherence issues with daily vitamin D replacement, an intermittent, high-dose vitamin D regimen cannot be supported as a strategy to reduce falls and fractures. (C) 2012 American Society for Bone and Mineral Research
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