Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 27, Issue 1, Pages 111-118Publisher
WILEY-BLACKWELL
DOI: 10.1002/jbmr.534
Keywords
MENOPAUSE; PERIMENOPAUSE; BONE MINERAL DENSITY; ETHNIC DIFFERENCES; LONGITUDINAL COHORT
Categories
Funding
- National Institutes of Health (NIH)
- DHHS through National Institute on Aging (NIA)
- National Institute of Nursing Research (NINR)
- NIH Office of Research on Women's Health (ORWH) [NR004061, AG012505, AG012535, AG012531, AG012539, AG012546, AG012553, AG012554, AG012495]
- NATIONAL INSTITUTE OF NURSING RESEARCH [U01NR004061] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG012546, U01AG012505, U01AG012495, U01AG012539, U01AG012553, U01AG012535, U01AG012531, U01AG012554] Funding Source: NIH RePORTER
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The objective of this study was to describe the time of onset and offset of bone mineral density (BMD) loss relative to the date of the final menstrual period (FMP); the rate and amount of BMD decline during the 5 years before and the 5 years after the FMP; and the independent associations between age at FMP, body mass index (BMI), and race/ethnicity with rates of BMD loss during this time interval. The sample included 242 African American, 384 white, 117 Chinese, and 119 Japanese women, pre- or early perimenopausal at baseline, who had experienced their FMP and for whom an FMP date could be determined. Loess-smoothed curves showed that BMD loss began 1 year before the FMP and decelerated (but did not cease) 2 years after the FMP, at both the lumbar spine (LS) and femoral neck (FN) sites. Piecewise, linear, mixed-effects regression models demonstrated that during the 10-year observation period, at each bone site, the rates and cumulative amounts of bone loss were greatest from 1 year before through 2 years after the FMP, termed the transmenopause. Postmenopausal loss rates, those occurring between 2 and 5 years after the FMP, were less than those observed during transmenopause. Cumulative, 10-year LS BMD loss was 10.6%; 7.38% was lost during the transmenopause. Cumulative FN loss was 9.1%; 5.8% was lost during the transmenopause. Greater BMI and African American heritage were related to slower loss rates, whereas the opposite was true of Japanese and Chinese ancestry. (C) 2012 American Society for Bone and Mineral Research
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