Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 25, Issue 12, Pages 2267-2276Publisher
WILEY-BLACKWELL
DOI: 10.1002/jbmr.234
Keywords
INSULIN-LIKE GROWTH FACTOR; GROWTH HORMONE BONE ACCRUAL; SKELETAL GROWTH; CORTICAL-BONE
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Funding
- United States (NIH) [AR054919, AR055141, AG-02331]
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Insulin-like growth factor-1 (IGF-1) plays a central role in cellular growth, differentiation, survival, and cell cycle progression It is expressed early during development and its effects are mediated through binding to a tyrosine kinase receptor, the insulin-like growth factor-1 receptor (IGF-1R) In the circulation, the IGFs bind to IGF-binding proteins (IGFBPs), which determine their bioavailability and regulate the interaction between the IGFs and IGF-1R Studies in animal models and in humans have established critical roles for IGFs in skeletal growth and development In this review we present new and old findings from mouse models of the IGF system and discuss their clinical relevance to normal and pathological skeletal physiology (C) 2010 American Society for Bone and Mineral Research
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