Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 24, Issue 5, Pages 935-942Publisher
WILEY
DOI: 10.1359/JBMR.081242
Keywords
25-hydroxyvitamin D; dietary calcium intake; BMD; adults; men and women
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Funding
- International Foundation for the Promotion of Nutrition Research and Nutrition Education (ISFE)
- Swiss Foundation for Nutrition Research (SFEFS)
- Swiss National Foundations
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A higher calcium intake is still the primary recommendation for the prevention of osteoporosis, whereas vitamin D deficiency is often not addressed. To study the relative importance of dietary calcium intake and serum 25-hydroxyvitamin D [25(OH)D] status in regard to hip BMD, 4958 community-dwelling women and 5003 men >= 20 yr of age from the U.S. NHANES III population-based survey were studied. Calcium supplement users and individuals with a prior radius or hip fracture were excluded. We calculated standardized means for BMD by quartiles of sex-specific calcium intake for three 25(OH)D categories (<50, 50-74, and 75+ nM) among men and women, separately controlling for other important predictors of BMD. A higher calcium intake was significantly associated with higher BMD 0) value for trend: p = 0.005) only for women with 25(OH)D status <50 nM, whereas calcium intake beyond the upper end of the lowest quartile (>566 mg/d) was not significantly, associated with BMD at 25(OH)D concentrations >50 nM. Among men, there was no significant association between a higher calcium intake beyond the upper end of the lowest quartile (626 mg/d) and BMD within all 25(OH)D categories. Among both sexes, BMD increased stepwise and significantly with higher 25(OH)D concentrations (<50, 50-74, 75+ nM, p value for trend: women < 0.0001; men 0.0001). Among men and women, 25(OH)D status seems to be the dominant predictor of BMD relative to calcium Intake. Only women with 25(OH)D concentrations <50 nM seem to benefit from a higher calcium intake.
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