Journal
ANTIVIRAL RESEARCH
Volume 123, Issue -, Pages 5-14Publisher
ELSEVIER
DOI: 10.1016/j.antiviral.2015.08.013
Keywords
Dengue; Dengue hemorrhagic fever; Animal models; Antiviral therapy; AG129 mice
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Funding
- Singapore Ministry of Health (MOH) Cat 1 industry collaboration grant [NMRC/MOHIAFCat1/0008/2014, NMRC/MOHIAFCat1/0018/2014]
- National Medical Research [(NMRC) NMRC/CBRG/0065/2014]
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Development of a suitable animal model for dengue virus disease is critical for understanding pathogenesis and for preclinical testing of antiviral drugs and vaccines. Many laboratory animal models of dengue virus infection have been investigated, but the challenges of recapitulating the complete disease still remain. In this review, we provide a comprehensive coverage of existing models, from man to mouse, with a specific focus on recent advances in mouse models for addressing the mechanistic aspects of severe dengue in humans. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery. (C) 2015 Elsevier B.V. All rights reserved.
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