Journal
JOURNAL OF BIOTECHNOLOGY
Volume 167, Issue 2, Pages 75-84Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbiotec.2012.07.008
Keywords
Cis, cis-muconic acid; Glucaric acid; 2-Oxoadipic acid; Benzoate; Escherichia coli; Pseudomonas sp.
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Funding
- Ministry of Innovation, Science and Research of North Rhine-Westphalia
- Heinrich Heine University Dusseldorf within the CLIB-Graduate Cluster Industrial Biotechnology
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Adipic acid is the most important commercial aliphatic dicarboxylic acid in the chemical industry and is primarily used for the production of nylon-6,6 polyamide. The current adipic acid market volume is about 2.6 million tons/y and the average annual demand growth rate forecast to stay at 3-3.5% worldwide. Hitherto, the industrial production of adipic acid is carried out by petroleum-based chemo-catalytic processes from non-renewable fossil fuels. However, in the past years, efforts were made to find alternative routes for adipic acid production from renewable carbon sources by biotechnological processes. Here we review the approaches and the progress made toward bio-based production of adipic acid. (C) 2012 Elsevier B.V. All rights reserved.
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