Journal
JOURNAL OF BIOTECHNOLOGY
Volume 163, Issue 2, Pages 133-142Publisher
ELSEVIER
DOI: 10.1016/j.jbiotec.2012.05.020
Keywords
Trichoderma; Genomics; Transcriptomics; Proteomics; Metabolomics; Cellulase; Hemicellulase
Categories
Funding
- Austrian Science Foundation [P19690, P21266, P23202]
- Federal Ministry of Economy, Family and Youth (BMWFJ)
- Federal Ministry of Traffic, Innovation and Technology (bmvit)
- Styrian Business Promotion Agency SFG
- Standortagentur Tirol and ZIT - Technology Agency of the City of Vienna through the COMET
- Austrian Science Fund (FWF) [P 21266] Funding Source: researchfish
- Austrian Science Fund (FWF) [P19690, P21266, P23202] Funding Source: Austrian Science Fund (FWF)
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Recent progress and improvement in -omics technologies has made it possible to study the physiology of organisms by integrated and genome-wide approaches. This bears the advantage that the global response, rather than isolated pathways and circuits within an organism, can be investigated (systems biology). The sequencing of the genome of Trichoderma reesei (teleomorph Hypocrea jecorina), a fungus that serves as a major producer of biomass-degrading enzymes for the use of renewable lignocellulosic material towards production of biofuels and biorefineries, has offered the possibility to study this organism and its enzyme production on a genome wide scale. In this review, I will highlight the use of genomics, transcriptomics, proteomics and metabolomics towards an improved and novel understanding of the biochemical processes that involve in the massive overproduction of secreted proteins. (C) 2012 Elsevier B.V. All rights reserved.
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