Journal
JOURNAL OF BIOTECHNOLOGY
Volume 146, Issue 3, Pages 143-146Publisher
ELSEVIER
DOI: 10.1016/j.jbiotec.2010.01.016
Keywords
Human embryonic stem cells; Extracellular matrix; RGD peptide; Biomaterials
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Funding
- US Department of Defense [W911NF-07-1-0072-RER5A]
- Army Research Office
- California Institute for Regenerative Medicine
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Human embryonic stem cells (hESCs) have numerous potential biomedical applications owing to their unique abilities for self-renewal and pluripotency. Successful clinical application of hESCs and derivatives necessitates the culture of these cells in a fully defined environment. We have developed a novel peptide-based surface that uses a high-affinity cyclic RGD peptide for culture of hESCs under chemically defined conditions. (C) 2010 Elsevier B.V. All rights reserved.
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