Journal
NEURAL REGENERATION RESEARCH
Volume 10, Issue 10, Pages 1537-1539Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.165215
Keywords
ischemic LTP (iLTP); stroke; neural repair; synaptic plasticity; neural homeostasis
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Funding
- German Israeli Foundation [G-1317-418.13/2015]
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The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation (iLTP) of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.
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