Journal
NEURAL REGENERATION RESEARCH
Volume 10, Issue 7, Pages 1125-1133Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.160109
Keywords
nerve regeneration; brain injury; epilepsy; neuroprotection; apoptosis; nuclear factor-kappa B;; brain inflammation; interleukin-6; interleukin-1 beta; inducible nitric oxide synthase; nitric oxide; prostaglandin E2; NSFC grant; neural regeneration
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Funding
- National Natural Science Foundation of China [81460208]
- Ningxia Natural Science Foundation of China [NZ13163]
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Amentoflavone is a natural biflavone compound with many biological properties, including anti-inflammatory, antioxidative, and neuroprotective effects. We presumed that amentoflavone exerts a neuroprotective effect in epilepsy models. Prior to model establishment, mice were intragastrically administered 25 mg/kg amentoflavone for 3 consecutive days. Amentoflavone effectively prevented pilocarpine-induced epilepsy in a mouse kindling model, suppressed nuclear factor-kappa B activation and expression, inhibited excessive discharge of hippocampal neurons resulting in a reduction in epileptic seizures, shortened attack time, and diminished loss and apoptosis of hippocampal neurons. Results suggested that amentoflavone protected hippocampal neurons in epilepsy mice via anti-inflammation, antioxidation, and antiapoptosis, and then effectively prevented the occurrence of seizures.
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