Journal
NEURAL REGENERATION RESEARCH
Volume 10, Issue 5, Pages 726-742Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.156966
Keywords
tissue engineering; neuroregeneration; repair; central nervous system; biomaterial; regenerative medicine; nanotechnology; spinal cord injury
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Funding
- Program IKY (Greek State Scholarships Foundation) Scholarships from funds of the Operational Program Education and Lifelong Learning, of the European Social Fund (ESF) of the National Strategic Reference Framework (NSRF)
- A.G. Leventis Foundation
- John S. Latsis Public Benefit Foundation
- Faculty of Medicine of the University of Thessaly (Greece)
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Spinal cord injury results in the permanent loss of function, causing enormous personal, social and economic problems. Even though neural regeneration has been proven to be a natural mechanism, central nervous system repair mechanisms are ineffective due to the imbalance of the inhibitory and excitatory factors implicated in neuroregeneration. Therefore, there is growing research interest on discovering a novel therapeutic strategy for effective spinal cord injury repair. To this direction, cell-based delivery strategies, biomolecule delivery strategies as well as scaffold-based therapeutic strategies have been developed with a tendency to seek for the answer to a combinatorial approach of all the above. Here we review the recent advances on regenerative/neural engineering therapies for spinal cord injury, aiming at providing an insight to the most promising repair strategies, in order to facilitate future research conduction.
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