Journal
NEURAL REGENERATION RESEARCH
Volume 10, Issue 1, Pages 84-89Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.150711
Keywords
nerve regeneration; peripheral nerve; sciatic nerve; traditional Chinese medicine; icariin; sleeve bridging suture; nerve growth factor; NSFC grants; neural regeneration
Categories
Funding
- National Program on Key Basic Research Project of China (973 Program) [2014CB542200]
- National Natural Science Foundation of China [31271284, 81171146, 31100860]
- Natural Science Foundation of Beijing of China [7142164]
- Program for Innovative Research Team in University of Ministry of Education of China [IRT1201]
Ask authors/readers for more resources
Our previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component of Epimedium extract, on peripheral nerve regeneration. A poly(lactic-co-glycolic acid) biological conduit sleeve was used to bridge a 5 mm right sciatic nerve defect in rats, and physiological saline, nerve growth factor, icariin suspension, or nerve growth factor-releasing microsphere suspension was injected into the defect. Twelve weeks later, sciatic nerve conduction velocity and the number of myelinated fibers were notably greater in the rats treated with icariin suspension or nerve growth factor-releasing microspheres than those that had received nerve growth factor or physiological saline. The effects of icariin suspension were similar to those of nerve growth factor-releasing microspheres. These data suggest that icariin acts as a nerve growth factor-releasing agent, and indicate that local application of icariin after spinal injury can promote peripheral nerve regeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available