Journal
JOURNAL OF BIOSCIENCES
Volume 36, Issue 3, Pages 471-479Publisher
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-011-9085-2
Keywords
DNA repair; heterochromatin; lamin; nuclear envelope; proteasome; ubiquitin ligases
Categories
Funding
- Department of Science and Technology
- Council of Scientific and Industrial Research
- Department of Biotechnology
Ask authors/readers for more resources
Lamins are major structural proteins of the nucleus and are essential for nuclear integrity and organization of nuclear functions. Mutations in the human lamin genes lead to highly degenerative genetic diseases that affect a number of different tissues such as muscle, adipose or neuronal tissues, or cause premature ageing syndromes. New findings on the role of lamins in cellular signalling pathways, as well as in ubiquitin-mediated proteasomal degradation, have given important insights into possible mechanisms of pathogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available