Journal
NEURAL REGENERATION RESEARCH
Volume 10, Issue 12, Pages 1989-1996Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.172317
Keywords
nerve regeneration; traditional Chinese medicine; salidroside; cerebral ischemia and reperfusion; nuclear factor erythroid 2-related factor 2; heme oxygenase-1; middle cerebral artery occlusion model; superoxide dismutase; neuroprotection; neural regeneration
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Funding
- Independent Research Project of Fujian Academy of Traditional Chinese Medicine in China [2012fjzyyk-4]
- Natural Science Foundation of Fujian Province in China [2014J01340]
- Fujian Provincial Health and Family Planning Commission [2014-ZQN-JC-32]
- Platform for Preclinical Studies of Traditional Chinese Medicine and Quality Control Engineering Technology Research Center of Fujian Province in China [2009Y2003]
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Salidroside, the main active ingredient extracted from Rhodiola crenulata, has been shown to be neuroprotective in ischemic cerebral injury, but the underlying mechanism for this neuroprotection is poorly understood. In the current study, the neuroprotective effect of salidroside on cerebral ischemia-induced oxidative stress and the role of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway was investigated in a rat model of middle cerebral artery occlusion. Salidroside (30 mg/kg) reduced infarct size, improved neurological function and histological changes, increased activity of superoxide dismutase and glutathione-S-transferase, and reduced malon-dialdehyde levels after cerebral ischemia and reperfusion. Furthermore, salidroside apparently increased Nrf2 and heme oxygenase-1 expression. These results suggest that salidroside exerts its neuroprotective effect against cerebral ischemia through anti-oxidant mechanisms and that activation of the Nrf2 pathway is involved. The Nrf2/antioxidant response element pathway may become a new therapeutic target for the treatment of ischemic stroke.
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