4.4 Article

Heat treatment of electrospun silicate fiber substrates enhances cellular adhesion and proliferation

Journal

JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 109, Issue 3, Pages 304-306

Publisher

SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/j.jbiosc.2009.08.482

Keywords

Silicate; Electrospinning; Sol-gel method; 3D-Cell culture; HepG2

Funding

  1. Japan Science and Technology Agency

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Synthetic scaffolds support cell attachment in vitro. We prepared ultra-fine silicate fibers using the sol-gel process and electrospinning, heated the fibers to 500 degrees C and investigated their effects on the behavior of human hepatocellular carcinoma (HepG2) cells. Alterations in surface composition following heat treatment improved cell adhesion and influenced cell migration. (C) 2009, The Society for Biotechnology, Japan. All rights reserved.

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