Journal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 108, Issue 5, Pages 446-449Publisher
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/j.jbiosc.2009.05.005
Keywords
Chromatin structure; Purification; iChlP; Epigenetics; Transcriptional regulation
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We established a novel method, insertional chromatin immunoprecipitation (iChlP), for isolation of specific genomic regions. In iChlP, specific genomic domains are immunoprecipitated with antibody against a tag, which is fused to the DNA-binding domain of an exogenous DNA-binding protein, whose recognition sequence is inserted into the genomic domains of interest. The iChlP method will be a useful tool for dissecting chromatin structure of genomic region of interest. (C) 2009, The Society for Biotechnology, Japan. All rights reserved.
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