Journal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 107, Issue 6, Pages 596-598Publisher
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1016/j.jbiosc.2009.01.023
Keywords
Pladienolide; Streptomycetes; Cytochrome P450 monooxygenase; One-pot; Fermentation
Funding
- Tsukuba Research Laboratories, Eisai Co., Ltd.
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Pladienolide D is a 16-hydroxylated derivative of pladienolide B, produced by Streptomyces platensis. To facilitate the production of pladienolide D, the gene encoding a pladienolide B 16-hydroxylase from S. bungoensis was introduced into S. platensis. The recombinant produced pladienolide D at a production level comparable to that of pladienolide B. (C) 2009, The Society for Biotechnology, Japan. All rights reserved.
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