Journal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 106, Issue 1, Pages 103-106Publisher
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1263/jbb.106.103
Keywords
anticancer drug; leaf spot fungus; Phyllosticta citricarpa; taxol production
Funding
- National Research Foundation of Korea [과C6A2604] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Phyllosticta citricarpa, a leaf spot fungus isolated from the diseased leaves of Citrus medica, displayed the production of taxol, an anticancer drug on MID and potato dextrose broth medium in culture for the first time. The presence of taxol was confirmed by spectroscopic and chromatographic methods of analysis. The maximum amount of taxol production was recorded in the fungus grown on M1D medium (265 mu g/l) followed by PDB medium (137 mu g/l). The production rate was increased to 5.3 x 10(3) fold than that observed in the culture broth of an earlier reported fungus, Taxomyces andreanae.
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