Journal
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
Volume 105, Issue 6, Pages 679-682Publisher
SOC BIOSCIENCE BIOENGINEERING JAPAN
DOI: 10.1263/jbb.105.679
Keywords
E-cadherin; co-culture; keratinocyte; hepatocyte; fibroblast; gene transfer
Funding
- Japan Society for the Promotion of Science (JSPS) [18048024, 19686049]
- Grants-in-Aid for Scientific Research [19686049, 18048024] Funding Source: KAKEN
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An epithelial cell adhesion molecule, E-cadherin was expressed in NIH3T3 fibroblasts, and cell-cell interactions between keratinocytes and fibroblasts, or between hepatocytes and fibroblasts were artificially engineered. When the E-cadherin-expressing NIH3T3 cells were co-cultured with rat hepatocytes, the cell-cell contacts were formed with high frequency, and enhanced albumin secretion was observed.
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