Journal
JOURNAL OF BIOPHOTONICS
Volume 8, Issue 7, Pages 584-596Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201400060
Keywords
Alzheimer's disease; differential diagnosis; blood serum; Raman spectroscopy; artificial neural networks
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Funding
- New York Capital Region Research Alliance Program
- National Institute on Aging, National Institutes of Health [R01AG033719]
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The key moment for efficiently and accurately diagnosing dementia occurs during the early stages. This is particularly true for Alzheimer's disease (AD). In this proof-of-concept study, we applied near infrared (NIR) Raman microspectroscopy of blood serum together with advanced multivariate statistics for the selective identification of AD. We analyzed data from 20 AD patients, 18 patients with other neurodegenerative dementias (OD) and 10 healthy control (HC) subjects. NIR Raman microspectroscopy differentiated patients with more than 95% sensitivity and specificity. We demonstrated the high discriminative power of artificial neural network (ANN) classification models, thus revealing the high potential of this developed methodology for the differential diagnosis of AD. Raman spectroscopic, blood-based tests may aid clinical assessments for the effective and accurate differential diagnosis of AD, decrease the labor, time and cost of diagnosis, and be useful for screening patient populations for AD development and progression.
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