Journal
JOURNAL OF BIOPHOTONICS
Volume 7, Issue 10, Pages 761-765Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201300043
Keywords
infrared nerve stimulation; plasmonic nanoparticles; photothermal effects; neuronal cells; intracellular calcium signalling; laser treatment
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Funding
- BBSRC [BB/E012981/1, BB/D524983/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E012981/1, BB/D524983/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/D524983/1, BB/E012981/1] Funding Source: Medline
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Uncoated and poly(styrene sulphonate) (PSS)-coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca2+ transients. The higher Ca2+ peaks were observed at lower laser doses, with the highest levels obtained at a radiant exposure of 0.33 J/cm(2). In contrast, the cells without nanoparticles showed a consistently small response, independent of the laser dose. These initial results open up new opportunities for peripheral nerve regeneration treatments and for more efficient optical stimulation techniques.
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