Journal
JOURNAL OF BIOPHOTONICS
Volume 7, Issue 8, Pages 581-588Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201200233
Keywords
optoacoustic tomography; photoacoustic imaging; nanoparticle concentration; carbon nanotubes; SWCNT; biodistribution
Categories
Funding
- National Institutes of Health (SBIR) [1R43ES021629, R44CA110137, R44CA110137-S1]
- Welch Foundation [C-0807]
Ask authors/readers for more resources
In this report, we demonstrate the feasibility of using optoacoustic tomography (OAT) to evaluate biodistributions of nanoparticles in animal models. The redistribution of single-walled carbon nanotubes (SWCNTs) was visualized in living mice. Nanoparticle concentrations in harvested organs were measured spectroscopically using the intrinsic optical absorption and fluorescence of SWCNTs. Observed increases in optoacoustic signal brightness in tissues were compared with increases in optical absorption coefficients caused by SWCNT accumulation. The methodology presented in this report can further be extended to calibrate the sensitivity of an optoacoustic imaging system for a range of changes in optical absorption coefficient values at specific locations or organs in a mouse body to enable noninvasive measurements of nanoparticle concentrations in vivo. Additionally, qualitative information provided by OAT and quantitative information obtained ex vivo may provide valuable feedback for advancing methods of quantitative analysis with OAT.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available