Journal
JOURNAL OF BIOPHOTONICS
Volume 5, Issue 7, Pages 536-543Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201100106
Keywords
optical clearing; permeability coefficient; breast cancer; glucose; mannitol; optical coherence tomography
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Funding
- National Natural Science Foundation of China [60778047]
- Natural Science Foundation of Guangdong Province [06025080]
- Key Science and Technology Project of Guangdong Province of China [2005B50101015, 2008B090500125]
- Key Science and Technology Project of Guangzhou City of China [2008Z1-D391]
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The potential of OCT applied for early breast cancer detection attracted significant efforts. The permeability coefficients and the percentages of OCT signal enhancement for normal and cancerous breast tissues have been investigated from the experiments of 20% glucose, 40% glucose, and 20% mannitol in vitro. Obtained results indicate that the permeability coefficient in breast cancer tissue is prominently larger than that in normal breast tissue, while the optical clearing effect is just the reverse to that for each agent. The results suggest that OCT has the ability to distinguish cancer tissue from different aspect. ((c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
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