Journal
JOURNAL OF BIOPHOTONICS
Volume 4, Issue 11-12, Pages 773-787Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201100062
Keywords
in-vivo optical properties; light propagation; PDT; laser-tissue interaction
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Funding
- Fontaine Foundation
- National Institute of Health (NIH) [RO1 CA109456, PO1 CA87971]
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A thorough understanding of optical properties of biological tissues is critical to effective treatment planning for therapies such as photodynamic therapy (PDT). In the last two decades, new technologies, such as broadband diffuse spectroscopy, have been developed to obtain in vivo data in humans that was not possible before. We found that the in vivo optical properties generally vary in the ranges mu(a) = 0.03 - 1.6 cm(-1) and mu'(s) = 1.2 - 40 cm(-1), although the actual range is tissue-type dependent. We have also examined the overall trend of the absorption spectra (for mu(a) and mu'(s)) as a function of wavelength within a 95% confidence interval for various tissues in vivo. The impact of optical properties on light fluence rate is also discussed for various light application geometries including superficial, interstitial, and within a cavity. Relative fluence rate, phi=phi(air), versus mu(eff) for various light source geometries for mu'(s) 10 cm(-1).
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