Journal
JOURNAL OF BIOPHOTONICS
Volume 3, Issue 3, Pages 125-129Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.200910069
Keywords
multi-spectral imaging; haemoglobin; melanin; skin chromophore mapping
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The multi-spectral imaging technique has been used for distant mapping of in-vivo skin chromophores by analyzing spectral data at each reflected image pixel and constructing 2-D maps of the relative concentration of oxy-/deoxy-haemoglobin and melanin. Instead of using a broad visible-NIR spectral range, this study focuses on narrowed spectral band 500-700 nm, speeding-up the signal processing procedure. Regression analysis confirmed that superposition of three Gaussians is optimal analytic approximation for the oxy-haemoglobin absorption tabular spectrum in this spectral band, while superposition of two fits well for deoxy-haemoglobin absorption and exponential function - for melanin absorption. The proposed approach was clinically tested for three types of in-vivo skin provocations: ultraviolet irradiance, chemical reaction with vinegar essence and finger arterial occlusion. Spectral range 500-700 nm provided sensitivity to oxy-haemoglobin changes and higher response stability to melanin than two reduced ranges 500-600 nm and 530-620 nm, (C) 2010 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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