Journal
JOURNAL OF BIOPHOTONICS
Volume 2, Issue 5, Pages 292-302Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.200910005
Keywords
nanoparticles; pharmacokinetics; biodistribution; cancer photothermal therapy
Categories
Funding
- RFBR [07-02-01434A, 08-0200399a, 07-04-00301a, 07-04-00302a, 09-0200496-a]
- Ministry of Science and Education of the Russian Federation by a Program on the Development of High School Potential [2.1.1/4989, 2.2.1.1/2950]
- President of the RF for the support of Leading Scientific Schools [208.2008.2, FP7-ICT.-2007-2]
- PHOTONICS4LIFE [224014]
- President of the Russian Federation (MK)
- Presidium of RAS Program The Basic Sciences - to Medicine
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Kinetics, biodistribution, and histological studies were performed to evaluate the particle-size, effects on the distribution of 15 nm and 50 nm PEG-coated colloidal gold (CG) particles and 160 nm silica/gold nanoshells (NSs) in rats and rabbits. The above nanoparticles (NPs) were used as a model because of their importance for current biomedical applications such as photothermal therapy, optical coherence tomography, and resonance-scattering imaging. The dynamics of NPs circulation in vivo was evaluated after intravenous administration of 15 nm CG NPs to rabbit, and the maximal concentrations of gold were observed 15-30 min after injection. Rats were injected in the tail vein with PEG-coated NPs (about 0.3 mg Au/kg rats). 24 h after injection, the accumulation of gold in different organs and blood was determined by atomic absorption spectroscopy. In accordance with the published reports, we observed 15 nm particles in all organs with rather smooth distribution over liver, spleen and blood. By contrast, the larger NSs were accumulated mainly in the liver and spleen. For rabbits, the biodistribution was similar (72 h after intravenous injection). We report also preliminary data on the light microscopy and TEM histological examination that allows evaluation of the changes in biotissues after gold NPs treatment. (C) 2009 by WILEYNCH Verlag GmbH & Co. KGaA, Weinheim
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