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Microfluidics and photonics for Bio-System-on-a-Chip: A review of advancements in technology towards a microfluidic flow cytometry chip

Journal

JOURNAL OF BIOPHOTONICS
Volume 1, Issue 5, Pages 355-376

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.200810018

Keywords

Biomedical instrumentation and transducers; including micro-electro-mechanical systems (MEMS); cells on a chip; other integrated-optical elements and systems; fabrication techniques; lithography; pattern transfer; flows in micro-electromechanical systems (MEMS) and nanoelectromechanical systems (NEMS); fluorescence

Funding

  1. NCRR NIH HHS [R21 RR024453-01, R21 RR024453] Funding Source: Medline
  2. NATIONAL CENTER FOR RESEARCH RESOURCES [R21RR024453] Funding Source: NIH RePORTER

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Microfluidics and photonics come together to form a field commonly referred to as 'optofluidics'. Flow cytometry provides the field with a technology base from which both microfluidic and photonic components be developed and integrated into a useful device. This article reviews some of the more recent developments to familiarize a reader with the current state of the technologies and also highlights the requirements of the device and how researchers are working to meet these needs A microfluidic flow cytometer prototype employing on-chip lenses for illumination and light collection in conjunction with a microfluidic sample flow system for device miniaturization.

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