Journal
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Volume 30, Issue 4, Pages 407-418Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2012.682207
Keywords
arginase; evolution dynamics; selective pressure
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Funding
- National Science Foundation of China [31100923]
- Jiangsu University Senior Personnel Research Grants [10JDG027]
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In the present study, a comprehensive analysis of the arginase gene family in metazoans was performed. A total of 126 arginase genes have been identified in 44 species. Phylogenetic analyses indicate that arginase genes consist of four groups. Conservative and divergent gene structures are found among the groups. The syntenies also exist in distantly related genomes among multiple species. Adaptive evolution shows that, while purifying selection may have been the main force driving the evolution of the arginases, some of critical sites responsible for the functional divergence may have been under positive selection. Overall, the data obtained from our investigation contribute to a better understanding of the complexity of the arginase gene family and of the function and evolution of this family in metazoans.
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