Journal
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
Volume 27, Issue 6, Pages 803-820Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/07391102.2010.10508585
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Funding
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1021681] Funding Source: National Science Foundation
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The DNA in eukaryotic chromatin is packed by histones into arrays of repeating units called nucleosomes. Each nucleosome contains a nucleosome core, where the DNA is wrapped around a histone octamer, and a stretch of relatively unconstrained DNA called the linker DNA. Since nucleosome cores occlude the DNA from many DNA-binding factors, their positions provide important clues for understanding chromatin packing and gene regulation. Here we review the recent advances in the genome-wide mapping of nucleosome positions, the molecular and structural determinants of nucleosome positioning, and the importance of nucleosome positioning in chromatin higher order folding and transcriptional regulation.
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